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Giant platelet disorder
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Giant platelet disorder : ウィキペディア英語版
Giant platelet disorder

Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelet disorder occurs for inherited diseases like Bernard-Soulier syndrome, gray platelet syndrome and May-Hegglin anomaly.
==Classification==
Giant platelet disorders can be further categorized:
* caused by auto-immune disorders, i.e. Immune Thrombocytopenic Purpura (ITP) , characterized by low platelet count, but high MPV (Mean-Platelet Volume).
* Caused by glycoprotein abnormalities: Bernard-Soulier syndrome, Velocardiofacial syndrome
* Caused by calpain defect: Montreal platelet syndrome
* Caused by alpha granules defect: Gray platelet syndrome
* Characterized by abnormal neutrophil inclusions: May-Hegglin anomaly, Sebastian syndrome
* With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome
* With no specific abnormalities: Mediterranean macrothrombocytopenia
* Harris platelet syndrome

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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