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Giant platelet disorder : ウィキペディア英語版 | Giant platelet disorder
Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelet disorder occurs for inherited diseases like Bernard-Soulier syndrome, gray platelet syndrome and May-Hegglin anomaly. ==Classification== Giant platelet disorders can be further categorized: * caused by auto-immune disorders, i.e. Immune Thrombocytopenic Purpura (ITP) , characterized by low platelet count, but high MPV (Mean-Platelet Volume). * Caused by glycoprotein abnormalities: Bernard-Soulier syndrome, Velocardiofacial syndrome * Caused by calpain defect: Montreal platelet syndrome * Caused by alpha granules defect: Gray platelet syndrome * Characterized by abnormal neutrophil inclusions: May-Hegglin anomaly, Sebastian syndrome * With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome * With no specific abnormalities: Mediterranean macrothrombocytopenia * Harris platelet syndrome
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